LCH.Clearnet to raise 300 mln stg, Nasdaq to up stake - report

Feb 27 (Reuters) - LCH.Clearnet will raise 300 million

pounds ($454 million) through a capital raising in the coming

days that is expected to see exchange operator Nasdaq OMX Group

raise its minority stake in the trans-Atlantic clearing

house, Sky News reported on Wednesday.

LCH Clearnet is in advanced stages of finalising the

fund-raising as part of a takeover deal by the London Stock

Exchange Group, Sky News said on its website.

The LSE plans to pay 366 million euros ($479.8 million) for

60 percent of LCH, which as a clearing house makes its money by

acting as a middle man in financial trades and guaranteeing to

complete deals if one of the parties involved can't.

The deal offers the LSE diversification from its equities

base into the many debt and currency markets in which LCH

operates, but the exchange has already cut its offer price after

estimating that regulatory demands could require LCH to raise

300 million euros in additional capital this year.

The two parties last month set a deadline giving themselves

until Thursday to finalise detailed terms of a deal and Sky News

said the companies are on the brink of an agreement even though

they could still miss the deadline.

LSE Group and LCH declined to comment.

As part of the deal, yet to be finalised as of Wednesday

afternoon, Singapore Exchange operator SGX could

potentially snap up a minority shareholding, while Nasdaq was

also in talks to raise its minority stake in the business, Sky

News said.

Nasdaq declined to comment. SGX could not be reached for

comment outside regular business hours.

Source: http://news.yahoo.com/lch-clearnet-raise-300-mln-stg-nasdaq-stake-214904578--sector.html

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Announcing the Insert Coin: New Challengers judges!

You've already voted for your favorite Insert Coin: New Challengers finalist, right? What? You haven't yet? What are you waiting for? Seriously. The voting's nearly closed! We've already whittled the list down to 10 finalists and asked you to help us get things down to five. Of course, there can only be one big winner, and for that we're bringing in the big guns.

MAKE Magazine Editor-in-Chief and Boing Boing co-editor Mark Frauenfelder will be joining us at Expand to help present the top five projects, each of whom will be getting time on our stage to convince readers and judges alike that they deserve to take home the top prize of $20,000. As for the judges themselves, we couldn't be happier -- the list includes four of the biggest names from the world of design, DIY, crowdfunding and gadget blogging. Check out the judges, after the break.

Filed under: Announcements

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Source: http://www.engadget.com/2013/02/27/insert-coin-judges/

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Bernanke defends Fed's low-interest-rate policies

WASHINGTON (AP) -- Facing criticism from Republican lawmakers, Chairman Ben Bernanke stood behind the Federal Reserve's low-interest-rate policies Wednesday and sought to reassure members of Congress that the central bank has a handle on the risks.

In his second day of testimony on Capitol Hill, Bernanke told members of the House Financial Services Committee that the Fed's bond purchases are needed to boost a still-weak economy and that they have helped create jobs for average Americans.

The bond purchases are intended to lower long-term interest rates. That encourages more borrowing and spending, which generates growth.

Still, some Republicans warned that by continually pumping more money into the financial system, the bond purchases could eventually ignite inflation.

"We have gone too far in monetary policy and the monetary easing, and it is in this member's opinion time to pull back," said Rep. Gary Miller, R-Calif.

Bernanke said the Fed is weighing the costs and benefits of its bond purchases. He noted that the Fed has a dual mandate: to both maximize employment and maintain low inflation.

His remarks during his semiannual monetary report to Congress largely repeated comments he made a day earlier to a Senate panel.

The Fed chairman argued that the Fed's low-interest-rate policies are giving crucial support to an economy still burdened by high unemployment. He also acknowledged the risks of keeping rates low indefinitely. But he expressed confidence that such risks pose little threat now and gave no signal that the Fed might shift away from those policies.

The aggressive program to buy $85 billion a month in Treasurys and mortgage bonds had kept borrowing costs low, he said. And that, in turn, has helped strengthen sectors such as housing and autos, he said. Still, unemployment remains high at 7.9 percent.

Bernanke rejected a suggestion by Rep. John Campbell, R-Calif., that the Fed's policies were mainly helping the federal government with its borrowing needs and big banks and foreign governments.

"This is very much focused at the average American citizen," Bernanke said. "Our estimates are that we've helped create many private-sector jobs. ... People are able to buy houses at very low mortgage rates, refinancing at low mortgage rates. People are able to get car loans at low rates."

The low borrowing rates have boosted demand, Bernanke said, and that has helped to lift home prices, making home owners feel more financially secure.

"In a lot of dimensions, we have, I think, benefited Main Street and that's certainly our objective," Bernanke said.

Source: http://news.yahoo.com/bernanke-defends-feds-low-interest-180917382.html

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Pope recalls 'joy,' difficulties in final audience

Pope Benedict XVI greets pilgrims in St. Peter's Square at the Vatican, Wednesday, Feb. 27, 2013 for the final time before retiring, waving to tens of thousands of people who have gathered to bid him farewell Benedict was driven around the square in an open-sided vehicle, surrounded by bodyguards. At one point he stopped to kiss a baby handed up to him by his secretary. (AP Photo/Luca Bruno)

Pope Benedict XVI greets pilgrims in St. Peter's Square at the Vatican, Wednesday, Feb. 27, 2013 for the final time before retiring, waving to tens of thousands of people who have gathered to bid him farewell Benedict was driven around the square in an open-sided vehicle, surrounded by bodyguards. At one point he stopped to kiss a baby handed up to him by his secretary. (AP Photo/Luca Bruno)

Pope Benedict XVI waves as he arrives for his last general audience in St. Peter's Square at the Vatican, Wednesday, Feb. 27, 2013. Tens of thousands of people toting banners saying "Thank you!" jammed St. Peter's Square on Wednesday to bid farewell to Pope Benedict XVI at his final general audience, the appointment he kept each week to teach the world about the Catholic faith. (AP Photo/Gregorio Borgia)

Pope Benedict XVI greets pilgrims in St. Peter's Square at the Vatican, Wednesday, Feb. 27, 2013. Pope Benedict XVI greeted the Catholic masses in St. Peter's Square Wednesday for the last time before retiring, making several rounds of the square as crowds cheered wildly and stopping to kiss a half-dozen children brought up to him by his secretary. (AP Photo/Michael Sohn)

A Vatican Swiss guard stands in front of St. Peter's Basilica at the Vatican, Wednesday, Feb. 27, 2013. Pope Benedict XVI is preparing for his final general audience, the weekly appointment he kept with the faithful and tourists to teach them about the Catholic faith. (AP Photo/Michael Sohn)

A man holds a cross as he stands in St. Peter's Square at the Vatican, Wednesday, Feb. 27, 2013. Pope Benedict XVI is preparing for his final general audience, the weekly appointment he kept with the faithful and tourists to teach them about the Catholic faith. (AP Photo/Michael Sohn)

VATICAN CITY (AP) ? Pope Benedict XVI bid an emotional farewell Wednesday on the eve of his retirement, recalling moments of "joy and light" during his papacy, but also times of difficulty when "it seemed like the Lord was sleeping."

Some 150,000 people, many waving banners proclaiming "Grazie!" flooded St. Peter's Square, eager to bear witness to the final hours of a papacy that will go down in history as the first in 600 years to end in resignation rather than death.

Benedict basked in the emotional send-off, taking a long victory lap around the square in an open-sided car, and stopping to kiss and bless half a dozen babies. Seventy cardinals, some tearful, sat in solemn attendance ? and gave him a standing ovation at the end of his speech.

Benedict then made a quick exit, forgoing the meet-and-greet session that typically follows his weekly general audience, as if to not prolong the goodbye.

Given the weight of the moment, Benedict also replaced his usual Wednesday catechism lesson with a heartfelt final address, explaining once again why he was retiring and assuring his flock of 1.2 billion that he was not abandoning them.

"To love the church means also to have the courage to take difficult, painful decisions, always keeping the good of the church in mind, not oneself," Benedict said to thundering applause.

He noted that a pontiff has no privacy ? neither as pope, nor in his future role as emeritus pope: "He belongs always and forever to everyone, to the whole church."

During his eight years as pope, Benedict said he had had "moments of joy and light, but also moments that haven't been easy. ... Moments of turbulent seas and rough winds, as has occurred in the history of the church, when it seemed like the Lord was sleeping."

But he said he never felt alone, that God always guided him, and he thanked his cardinals and colleagues for their support and for "understanding and respecting this important decision."

The pope's tenure has been beset by the clerical sex abuse scandal, discord over everything from priestly celibacy to women's ordination, and most recently the betrayal by his own butler, who stole his private papers and leaked them to a journalist.

Under a bright sun and blue skies, the square was overflowing with pilgrims and curiosity-seekers. Those who couldn't get in watched on giant TV screens set up along the main boulevard leading to the square. About 50,000 tickets were requested, and in the end, the Vatican estimated that 150,000 people flocked to the farewell.

"It's difficult ? the emotion is so big," said Jan Marie, a 53-year-old Roman in his first years as a seminarian. "We came to support the pope's decision."

With chants of "Benedetto!" the mood was far more buoyant than during the pope's final Sunday blessing. It recalled the jubilant turnouts that often accompanied him at World Youth Days and events involving his predecessor, Pope John Paul II.

Benedict has said he decided to retire after realizing that, at 85, he simply didn't have the "strength of mind or body" to carry on.

"I have taken this step with the full understanding of the seriousness and also the novelty of the decision, but with a profound serenity in my soul," Benedict told the crowd.

He will meet Thursday morning with his cardinals for a final time, then fly by helicopter to the papal residence at Castel Gandolfo south of Rome.

There, at 8 p.m., the doors of the palazzo will close and the Swiss Guards in attendance will go off duty, their service protecting the head of the Catholic Church over ? for now.

Many of the cardinals who will choose Benedict's successor were in St. Peter's Square for his final audience. Among them was retired Los Angeles Cardinal Roger Mahony, the object of a grass-roots campaign in the U.S. to persuade him to recuse himself for having covered up for sexually abusive priests. Mahony has said he will be among the 115 cardinals voting for the next pope.

"God bless you," Mahony said when asked by television crews about the U.S. campaign.

Also in attendance were cardinals over 80, who can't participate in the conclave but will take part in meetings next week to discuss the problems facing the church and the qualities needed in a new pope.

"I am joining the entire church in praying that the cardinal electors will have the help of the Holy Spirit," 82-year-old Spanish Cardinal Julian Herranz said.

Herranz has been authorized by the pope to brief voting-age cardinals on his investigation into the leaks of papal documents that exposed corruption in the Vatican administration.

Vatican officials say cardinals will begin meeting Monday to decide when to set the date for the conclave.

Still, the rank-and-file faithful weren't so concerned with the future: They wanted to savor the final moments of a pope they have known for years.

"I came to thank him for the testimony that he has given the church," said Maria Cristina Chiarini, a 52-year-old homemaker who traveled by train from Lugo in central Italy with about 60 members of her parish. "There's nostalgia, human nostalgia, but also comfort. Because as Christians we have hope. The Lord won't leave us without a guide."

___

Follow Nicole Winfield at www.twitter.com/nwinfield

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-27-Vatican-Pope/id-4dc014d20c684f97ba368a0d9cf03322

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Litvinenko lawyer accuses UK, Russia of cover-up

LONDON (AP) ? A lawyer for the family of former Russian spy Alexander Litvinenko accused the British and Russian governments Tuesday of trying to stymie a long-delayed inquest into his poisoning death.

Litvinenko, a Russian intelligence agent turned Kremlin critic, died in London in November 2006 after drinking tea laced with the rare radioactive isotope polonium-210.

The allegations of a cover-up came at a London court hearing where British media organizations challenged a government bid to hold parts of the inquest in secret for security reasons. In Britain, inquests are held to determine the facts whenever someone dies violently, unexpectedly or in disputed circumstances.

Ben Emmerson, the lawyer for Litvinenko's widow Marina, said the government's quest for secrecy was delaying proceedings and suggested that foreign policy ? namely trade relations ? could be at the heart of the matter.

"We know nothing about why these applications are being made and we are dancing in the dark," he told coroner Robert Owen. "This is beginning to look like you're being steamrollered by two states acting in collaboration with each other."

Lawyers for Litvinenko's family say at the time of his death he was working for the British intelligence services, and Britain accuses two Russians of the killing. Moscow authorities have refused to extradite them for trial.

British government lawyer Neil Sheldon said "the disclosure of the material in question would pose a real risk to the public interest."

Emmerson ? who said the inquest is "shaping up to be a stain on British justice" ? called the government's arguments for secrecy absurd.

Alex Bailin, the lawyer representing prominent British media organizations, insisted at the very least the government must clarify what issues are at stake and what harm they could cause.

Failing to do so, he said, "would have the very serious effect of undermining the public's confidence in this inquest."

The inquest was due to start May 1. But Owen, the coroner, said Tuesday he was "becoming increasingly concerned that due to the complexity of the investigation which necessarily precedes the hearings, that may be a timetable to which it may not be possible to adhere."

The Litvinenko process has been delayed until now because, for a long time, officials thought there was a chance the Russian suspects could be prosecuted. But last year, it became clear that the U.K. would not be able to put the two suspects on trial.

Emmerson said Marina Litvinenko was "extremely disappointed" by the prospect of further delays.

"Not as disappointed as me," Owen said.

The hearing was adjourned until Wednesday.

___

Cassandra Vinograd can be reached at http://twitter.com/CassVinograd

___

Online: www.litvinenkoinquest.org

Source: http://news.yahoo.com/litvinenko-lawyer-accuses-uk-russia-cover-145651260.html

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SES New York Keynote Speaker Says Internet is TV's Best Friend ...

The Internet didn?t kill TV! According to Mike Proulx, the Internet has become TV?s best friend. Proulx will be the opening keynote speaker at SES New York 2013. The leading event for experienced marketing and advertising professionals will take place March 25-28, 2013, at the New York Marriott Marquis.

Proulx is a Senior Vice President and the Director of Social Media at Hill Holliday, a renowned advertising agency based in Boston, where he leads a team with a focus on cross-channel integration, emerging and social media. He has spent the last 17 years working at various interactive, high-tech, and new media companies on the agency-side, client-side, and as an entrepreneur. He has spoken at dozens of events and has been widely featured in the press including The New York Times, Fast Company, TV Guide, Forbes, BusinessWeek, Mashable, BuzzFeed, and NPR.

Proulx conceived, produced, directed, and co-host the TVnext summit, which took place in early 2011 and 2012. He is the co-author of Social TV, a best-selling book from Wiley publishing that launched in February of 2012. He is also the host of the social TV web series, ?The Pulse on Lost Remote?. He holds a Master?s degree in Computer Information Systems from Bentley University and in 2012 was named the Ad Club?s Media All Star.

His opening keynote is titled, ?Social TV: How Marketers Can Reach and Engage Audiences by Connecting Television to the Web, Social Media, and Mobile.?

Search Engine Watch (SEW) asked Mike Proulx (MP) five questions about his upcoming keynote. Here are his answers:

SEW: How does the convergence of television with the web, social media, and mobile change our behaviors and shake up our long standing beliefs about TV?

MP: There are those who believe that television is a traditional medium with an impending death. The web, social media, and mobile have evolved TV into a multi-screen experience that transcends devices. Not only are we watching more television than ever before, we?re interacting with programming on the ?second screen? in ways that enrich storylines and bring us together to virtually co-view. The modern era of television is a new media that?s more social, more connected, and more portable?and because of this TV is more alive than it?s ever been.

SEW: How has social media created a new and powerful "backchannel" and why does this fuel the renaissance of live broadcasts?

MP: There are a ton of posts happening in social media about any given TV show as it airs. Since Twitter is open and public, it acts as television?s backchannel filled with real-time commentary and conversation ? And it?s not just about TV series but also TV commercials giving producers and marketers instant feedback about their content. Live television events are seeing some of the highest ratings in years and social media brings a level of community and connection to TV watching the likes of which the medium has never before experienced.

SEW: Can you give us some examples of how mobile devices allow us to watch and interact with television whenever and wherever we want?

MP: Tablets, smartphones, and laptops enable television?s portability but it?s apps like HBO Go, ABC Player, Xfinity Remote, and CNN that deliver ?TV? content via those devices. And in the 4G world of mobile, we can watch TV in places once inconceivable. My favorite spot? Laying out on the roof deck on a warm summer night with my iPad in hand streaming HBO?s The Newsroom.

SEW: Why would ?connected TVs? blend web and television content into a unified big screen experience that will bring us back into our living rooms?

MP: Apple TV, Roku, Boxee TV, Google TV, Samsung Smart TVs, etc. stream online video (that was once relegated to our computer screens) onto the ?big screen? of our living rooms. HD YouTube clips suddenly come to life in ways that are far more impactful and dynamic than tiny smartphone screens further blurring the lines of what?s ?TV.? While the notion of TV everywhere lets us watch TV at will regardless of our physical location, the increasingly seamless ability to channel streaming video through the TV set makes the living room that much more compelling.

SEW: With the television landscape changing, why should brands approach the medium once labeled ?traditional? as new media?

MP: TV has become mashed up with the Web, social media, and mobile. Television networks, providers, brands, and agencies must continue to unshackle themselves from dated business and advertising models and rediscover television as a new medium. This means planning television and digital together to tell stories across devices and engage viewers with TV experiences not just TV shows. The speed, scale, and degree of change that has and is happening create enormous opportunity for those brands who have the courage to innovate.

SES New York 2013 offers a variety of conference passes and on-site training. If you register by Thursday, March 7, 2013, you can save up to $600 on Platinum or All Access passes.

For more information, click on Rates and Registration Details. Group discounts for 4 or more pass holders from the same company are also available by contacting [email?protected] and are the best value for the lowest price possible.

I should disclose that SES New York is a client of my agency. But, trust me, TV is not dead yet.

---

Become an Expert Digital Marketer at SES New York
March 25-28, 2013: With dozens of sessions on Search, Social, Local and Mobile, you'll leave SES with everything and everyone you need to know. Hurry, early bird rates expire February 21. Register today!

Source: http://searchenginewatch.com/article/2250850/SES-New-York-Keynote-Speaker-Says-Internet-is-TVs-Best-Friend

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Horse meat found in Ikea's Swedish meatballs

STOCKHOLM (AP) ? Swedish furniture giant Ikea was drawn into Europe's widening food labeling scandal Monday as authorities said they had detected horse meat in frozen meatballs labeled as beef and pork and sold in 13 countries across the continent.

The Czech State Veterinary Administration said that horse meat was found in one-kilogram (2.2 pound) packs of frozen meatballs made in Sweden and shipped to the Czech Republic for sale in Ikea stores there. A total of 760 kilograms (1,675 pounds) of the meatballs were stopped from reaching the shelves.

Ikea spokeswoman Ylva Magnusson said meatballs from the same batch had gone out to Slovakia, Hungary, France, Britain, Portugal, the Netherlands, Belgium, Spain, Italy, Greece, Cyprus and Ireland. Magnusson said meatballs from that batch were taken off the shelves in Ikea stores in all those countries. Other shipments of meatballs were not affected, including to the U.S., even though they all come from the same Swedish supplier, Magnusson said.

"Our global recommendation is to not recall or stop selling meatballs," she said.

However, the company's Swedish branch announced on its Facebook page that it won't sell or serve any meatballs at its stores in Sweden out of concern for "potential worries among our customers."

Magnusson said Ikea saw no reason to extend that guidance globally. She said Ikea was conducting its own tests of the affected batch "to validate" the Czech results. She also said that two weeks ago Ikea tested a range of frozen food products, including meatballs, and found no traces of horse meat.

"But, of course, we take the tests that Czech authorities have done very seriously," Magnusson said. "We don't tolerate any other ingredients than those on the label."

Ikea's trademark blue-and-yellow stores typically feature a restaurant that serves traditional Swedish food, including meatballs served with boiled or mashed potatoes, gravy and lingonberry jam. Meatballs ? "Kottbullar" in Swedish ? are also available in the frozen foods section.

Magnusson said all of the meatballs are supplied by Gunnar Dafgard AB, a family-owned frozen foods company in southwestern Sweden. Calls to the company were not immediately returned.

European Union officials were meeting Monday to discuss tougher food labeling rules after the discovery of horse meat in a range of frozen supermarket meals such as burgers and lasagna that were supposed to contain beef or pork.

The Czech authority also announced Monday that it found horse meat in beef burgers imported from Poland during random tests of food products.

Spanish authorities, meanwhile, announced that traces of horse meat were found in a beef cannelloni product by one of the brands of Nestle, a Switzerland-based food giant. The Agriculture Ministry said it was a case of fraudulent labeling but represented no health threat.

In a statement on its website, Nestle Spain said that after carrying out tests on meat supplied to its factories in Spain it was withdrawing six "La Cocinera" products and one "Buitoni" product from store shelves.

It said it was taking the action after the traces of horse meat were found in beef bought from a supplier in central Spain. Nestle said it was taking legal action against the company, adding that the products would be replaced by ones with 100 percent beef.

Some EU member states are pressing for tougher labeling rules to regain consumer confidence.

The 27-nation bloc must agree on binding origin disclosures for food product ingredients, starting with a better labeling of meat products, German Agriculture Minister Ilse Aigner said.

"Consumers have every right to the greatest-possible transparency," she insisted.

Austria backs the German initiative; but others like Ireland say existing rules are sufficient although Europe-wide controls must be strengthened to address the problem of fraudulent labeling.

The scandal has created a split between nations like Britain which see further rules as a protectionist hindrance of free trade under the bloc's single market, and those calling for tougher regulation.

Processed food products ? a business segment with traditionally low margins that often leads producers to hunt for the cheapest suppliers ? often contain ingredients from multiple suppliers in different countries, who themselves at times subcontract production to others, making it hard to monitor every link in the production chain.

Standardized DNA checks with meat suppliers and more stringent labeling rules will add costs that producers will most likely hand down to consumers, making food more expensive.

The scandal began in Ireland in mid-January when the country announced the results of its first-ever DNA tests on beef products. It tested frozen beef burgers taken from store shelves and found that more than a third of brands at five supermarkets contained at least a trace of horse. The sample of one brand sold by British supermarket kingpin Tesco was more than a quarter horse.

Such discoveries have spread like wildfire across Europe as governments, supermarkets, meat traders and processors began their own DNA testing of products labeled beef and have been forced to withdraw tens of millions of products from store shelves.

More than a dozen nations have detected horse flesh in processed products such as factory-made burger patties, lasagnas, meat pies and meat-filled pastas. The investigations have been complicated by elaborate supply chains involving multiple cross-border middlemen.

___

Associated Press writers Juergen Baetz in Brussels, Karel Janicek in Prague and Ciaran Giles in Madrid contributed to this report.

Source: http://news.yahoo.com/horse-meat-found-ikeas-swedish-meatballs-112154426--finance.html

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Church with German Alps in Ramsau, Bavaria by Frank Fischbach

That is taken in Ramsau in the Bavarian Alps. The location is called "Malerwinkel" (specifc place for painters).
I was quite cold that morning, less than -10 C?. I took a couple of shots there with different compositions. This is a blend of two exposures: The lower part was done with a Lee ND filter (2 stops) and F/16 to get the water soft, but the upper part was overexposed. Upper part shot with F/10 for best sharpness. Some processing of the colors and some extra structure for the rocks in the foreground later.
I used my new Tamron 24-70 mm 2,8 which I like.

• Camera Canon EOS 5D Mark III
• Focal Length 70mm
• Shutter Speed 1/25 sec
• Aperture f/10
• ISO/Film 100
• Category Landscapes
• Uploaded About 4 hours ago
• Taken February 11th 2013
• Copyright Frank Fischbach

Source: http://feed.500px.com/~r/500px-upcoming/~3/A_LV2efrIQ4/26640549

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Pakistan on the verge of defeat against South Africa

CENTURION: A run-out shortly after lunch sparked a collapse as Pakistan slid towards defeat on the third day of the third and final Test against South Africa at SuperSport Park on Saturday.

Pakistan were 187 for seven at tea, still 66 runs short of an innings defeat which would complete a 3-0 series sweep for South Africa.

An early finish seemed in prospect when Pakistan lost four wickets quickly after lunch to be floundering at 114 for six, but Sarfraz Ahmed (27 not out) and Saeed Ajmal (30 not out) batted enterprisingly and with a modicum of luck to put on an unbeaten 62 for the seventh wicket.

Azhar Ali and Imran Farhat defied the South African bowlers for most of a morning during which only the wicket of Younis Khan fell.

They saw Pakistan through to lunch at 87 for two, with Azhar on 27, eked out over 110 balls.

But Azhar did not face another ball before he was run out by a superb throw from fine leg by Dale Steyn after being sent back by Farhat, who had initially been seeking a second run.

Pakistan's hopes of avoiding an innings defeat crumbled as three more wickets fell in quick succession.

Farhat was caught behind, slashing at first innings bowling hero Kyle Abbott for 43 and without addition to the score Pakistan captain Misbah-ul-Haq edged an away-swinger from Rory Kleinveldt to wicketkeeper AB de Villiers.

Asad Shafiq made only six before he drove Kleinveldt to mid-off. But Sarfraz and Ajmal showed spirit in batting through until tea.

Source: http://www.allvoices.com/contributed-news/14107897-pakistan-on-the-verge-of-defeat-against-south-africa

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Study reveals new clues to Epstein-Barr virus

Friday, February 22, 2013

Epstein-Barr virus (EBV) affects more than 90 percent of the population worldwide and was the first human virus found to be associated with cancer. Now, researchers from Beth Israel Deaconess Medical Center (BIDMC) have broadened the understanding of this widespread infection with their discovery of a second B-cell attachment receptor for EBV.

The new findings, which currently appear on-line in Cell Reports, reinforce current directions being taken in the development of a vaccine to guard against EBV, and raise important new questions regarding the virus's possible relationship to malaria and to autoimmune diseases.

"Our discovery that CD35 is an attachment receptor for EBV helps explain several previously unsolved observations," explains the study's senior author Joyce Fingeroth, MD, a member of the Division of Infectious Diseases at BIDMC and Associate Professor of Medicine at Harvard Medical School.

First discovered in the early 1960s, EBV is one of eight viruses in the human herpesvirus family. The virus affects nine out of 10 people at some point in their lifetimes. Infections in early childhood often cause no disease symptoms, but people infected during adolescence or young adulthood may develop infectious mononucleosis. EBV is also associated with several types of cancer, including Hodgkin's lymphoma, non-Hodgkin's lymphoma and nasopharyngeal carcinoma, and has been linked to certain autoimmune disorders.

"EBV was the first human virus that was discovered to be a tumor virus," explains Fingeroth. "In fact, individuals who have had infectious mononucleosis have a four times increased risk of developing Hodgkin's disease." After the initial infection, the EBV virus remains in a person's body for life.

To gain entry, viruses must first attach to their host cells. For herpesviruses, receptors on the viral envelope become connected to complementary receptors on the cell membrane. In the case of EBV, the virus gains access to the immune system by attaching to primary B cells.

Nearly 30 years ago, Fingeroth and her colleagues discovered that this attachment occurs via the CD21 protein, which until now was the only known B cell attachment receptor for EBV. The recent finding that B cells from a patient lacking CD21 can be infected and immortalized by EBV had indicated that an alternative attachment receptor must exist. The identification of this second receptor -- CD35 -- by Fingeroth's team, led by first author Javier Ogembo, PhD, of BIDMC and the University of Massachusetts Medical School, not only underscores an important finding regarding primary infection but also underscores the importance of EBVgp350/220, (the virus protein that has been found to bind to both attachment receptors) for the development of a vaccine against EBV.

"The EBV glycoprotein gp350/220 is the most abundant surface glycoprotein on the virus," notes Fingeroth, adding that these results further suggest the virus fusion apparatus is the same for both receptors. "An EBV vaccine might be able to prevent infection or, alternatively, greatly reduce a person's risk of developing infectious mononucleosis and EBV-associated cancers, without necessarily preventing the EBV infection itself."

Interestingly, she adds, whereas a human has now been identified to be lacking the CD21 receptor, no persons are known to lack CD35.

"CD35 is a latecomer in evolution and in its current form, exists only in humans," says Fingeroth. "We know that it is often targeted in autoimmune diseases and was recently identified as a malaria receptor. Our new discovery may, therefore, reveal new avenues for the exploration of unexplained links between EBV, autoimmune diseases, malaria and cancer."

###

Beth Israel Deaconess Medical Center: http://www.bidmc.harvard.edu

Thanks to Beth Israel Deaconess Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126972/Study_reveals_new_clues_to_Epstein_Barr_virus

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Royal Bank of Scotland to cut jobs in India

Royal Bank of Scotland has planned to lay off a number of employees in India.

The move comes as part of a plan to wind down its retail and commercial business in India.

A bank spokeswoman said that the affected employees are being informed, but didn't provide details such as how many people will be affected by the job cut.

According to the Wall Street Journal, the spokeswoman added that there is no impact on RBS's markets, international banking and private banking businesses in India.

The British bank has been looking for buyers for its retail and commercial business, which it says is no more core to its India strategy.

The division, which provides loans to individuals and small businesses, had total assets of 190 million pounds at the end of September.

RBS "continues to review all options," the spokeswoman said about its plan to sell the division in India, the paper added.

Tags: Royal Bank of Scotland, RBS jobs cut, RBS India, banking news

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Source: http://www.indianexpress.com/news/royal-bank-of-scotland-to-cut-jobs-in-india/1078639/

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Alleged Galaxy S IV Cases Sprout Up On The Web

A handful of cases seem to have leaked out for the forthcoming Galaxy S IV smartphone from Samsung. Since the phone has not yet been announced, we should approach each and every one of these cases with a hearty helping of salt. However, sometimes case makers get their hands on information we don't quite have, such as dimensions, meaning their cases can shed some light on what's coming next. In this particular case, the Galaxy S IV cases are coming from "a trusted Chinese case manufacturer," according to MobileFun, and are ready to support a phone with a 5-inch display.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/17sNaNUzsQA/

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Tiny tweezers and their big influence on bustling proteins: Scientists investigate molecular 'clothespins'

Feb. 22, 2013 ? Tiny molecular tweezers have a remarkable impact on bustling proteins: Three research groups from the University of Duisburg-Essen (UDE), the Chemical Genomics Centre of the Max Planck Society in Dortmund and the Max Planck Institut f?r Kohlenforschung in M?lheim found that the molecular tweezers designed by Professor Frank Kl?rner at the UDE can be used to regulate protein -- protein interactions by selectively trapping certain residues of the protein -- and stick like a clothespin.

The research groups of Thomas Schrader (UDE), Christian Ottmann (Chemical Genomics Centre) and Elsa Sanchez Garcia (MPI f?r Kohlenforschung) believe that this might be a promising approach for applications in medical research, as the water soluble tweezers act without inducing toxicity or explicit side effects.

The scientists have tested their small tweezers on proteins that have influence on many processes in the human body. "We also wanted to know how they work," says Dr. Elsa Sanchez Garcia, leader of a Max Planck research group at the Max Planck Institut f?r Kohlenforschung. The chemists have found out that although their tweezers prefer to bind at the amino acid lysine, the protein surrounding of the lysine influences the trapping of the tweezers. Thus, with computer simulations Dr. Sanchez Garcia and her colleague Kenny Bravo Rodriguez have shown which type of lysine the tweezers prefer -- and why that is the case. Their work also allowed to lay down rules for predicting the behavior of the tweezers in the presence of proteins with several lysine residues.

Although the tweezers research is at early stages, their potentiality makes it worth for medical researchers to have a closer look at these results. The 14-3-3 adapter proteins (14-3-3) that the scientists used for their experiments are small recognition proteins that influence many physiological processes by binding their targets via short peptide sequences and modulating their function. For instance, they are able to stabilize certain tumor suppressors. Because of their important role in many biological processes, 14-3-3 proteins are prospective therapeutic agents against severe disorders, such as cancer.

The three research groups published their findings in the Nature Chemistry.

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The above story is reprinted from materials provided by Max-Planck-Institut f?r Kohlenforschung.

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Journal Reference:

1. David Bier, Rolf Rose, Kenny Bravo-Rodriguez, Maria Bartel, Juan Manuel Ramirez-Anguita, Som Dutt, Constanze Wilch, Frank-Gerrit Kl?rner, Elsa Sanchez-Garcia, Thomas Schrader, Christian Ottmann. Molecular tweezers modulate 14-3-3 protein?protein interactions. Nature Chemistry, 2013; 5 (3): 234 DOI: 10.1038/nchem.1570

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/zFmxxgQoyMo/130222102648.htm

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James Marsden Joins Anchorman: The Legend Continues

I?m trying really hard to control my excitement for Anchorman: The Legend Continues. I know that sequels to beloved originals ? especially comedies ? are often disappointments. I know the lightning rarely strikes in the same place twice. I know ? but I can hope. This latest news, though, makes it really difficult for me not to run around the apartment screaming ?You guys! You Guys! Seriously! Oh my God, you guys!? Because James Marsden has been cast as Ron Burgundy?s nemesis.

The only information that we have right now is that Marsden has been cast as a rival anchor, but of course that could mean anything. What is exciting about this is that it?s another, excellent addition to the original cast ? which includes Will Ferrell, Steve Carell, Paul Rudd, and Christina Applegate, all back in their original parts. Marsden has proven that he can play comedy, even if the film surrounding him sometimes leaves something to be desired (I?m looking at you, Sex Drive). And who better to stand up again Burgundy than the quaffed, blue-eyed Marsden with his giga-watt smile? I can see all kinds of comedic possibilities here.

Marsden is a confirmed addition to the cast, joining fellow newcomer Kristen Wiig, who we think is playing Brick Tamland?s (Steve Carell) wife. Nice to see some quality newbies joining up with the original team.

We shall have to wait and see what the folks behind Anchorman: The Legend Continues have up their sleeves. Will Marsden team up with Vince Vaughn?s Wes Mantooth? Will Burgundy?s mustache be threatened? And will we have another flute solo? Only director Adam McKay knows for sure.

Production on Anchorman: The Legend Continues begins in March. We?ll keep you updated on casting decisions as they come in. Until then: stay classy, San Diego. (Sorry, I had to do it.)

Source: http://www.rottentomatoes.com/m/1926895/news/1926895/

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A Mini mindset: how an automaker's Connected platform could spark a seismic shift in infotainment expectations

Mini sold some 66,000 vehicles in the United States last year, and despite being on American soil (in its current incarnation, anyway) for just 13 years, this market has quickly become its biggest. Those drawn to the brand are likely intrigued by, if not outright enamored of, its quirkiness. Mini likes to say that the company is "Not Normal," and it only takes a glance inside its cartoonish Countryman to see what that means.

During a recent kickoff event to celebrate the impending launch of its Paceman model, we sought to get beneath the sheet metal and gear ratios, instead looking at the kinds of decisions that impact the marriage of automobiles and technology. Turns out, Johnly Velasquez and Chris Potgieter -- two gentlemen in charge of determining what technology ends up in Mini products -- were more than happy to discuss those nuances. In particular, we discussed how those details relate to the future of its Connected platform, the role that infotainment plays in its entire range of motorcars and the opportunities that lie ahead for Mini to embrace alternative power.

Could Mini's prioritization of technology as a pillar of automotive manufacturing influence the entire industry? That's exactly what we'll explore just beyond the break.

Gallery: 2013 Mini Paceman launch gallery

Filed under: Transportation

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Source: Mini

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Ixv3-1zUM5Y/

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Missouri GOP Tries Once Again To Force Schools To Teach Creationism As Real Science

In 2012, Republicans in Missouri tried to hijack the science curriculum in an attempt to force students to learn creationism, also known as intelligent design. Fast forward one year later and Republicans in the state refuse to give up on their dream of poisoning the subject with religion.

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House Bill 291, as introduced by conservative state Rep. Rick Brattin, would require creationism to be given equal time with evolution in science classes and all textbooks would be required to devote the same number of pages to creationism as they do to evolution. The bill includes multiple sections and subsections on the teaching of creationism, referring to the subject as ?biological intelligence? and ?faith-based philosophical belief.?

The bill blatantly attempts to redefine science, and includes new and strange definitions of ?analogous naturalistic processes,? ?biological evolution,? ?empirical data,? ?hypothesis,? ?origin,? ?scientific theory,? ?scientific law,? and ?standard science.? According to Eric Meikle of the National Center for Science Education in an interview with Mother Jones:

?This bill is very idiosyncratic and strange. And there is simply not scientific evidence for intelligence design,? and could ?open the door for teachers who are opposed to evolution to bring in creationist materials.?

The bill would also make science more tedious to teach because it allows any other origin theory to be taugh,t which opens up the classroom to ANY theory in existence, wasting the valuable and short amount of time teachers need to teach real science.

Science is a subject governed by fact, not faith. Scientific knowledge comes from observation and experimentation, both of which cannot be used to support intelligent design. Religion does not belong in science class. It belongs in church. Teaching a religious theory in class has the great potential to cause division among students and would most certainly cost schools a great deal of money to not only purchase new textbooks, but to pay court and attorney fees when some parents decide to sue the school for trying to indoctrinate their kids with religion against their will. Those are just a few reasons to keep religion out of science class.

Clearly, Republicans intend to keep pushing these creationism bills in any and every state. So far, they have only managed to pass such bills in Louisiana and Tennessee. If America is going to lead the world in science once again, creationism must not be allowed in science classrooms. Creationism and science simply cannot co-exist and we would be a worldwide laughingstock if we allowed our science classrooms to become purveyors of religious doctrine. Science is fact. Religion is faith. And only one belongs in schools.

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Tags: creationism, education, evolution, HB 291, Missouri, religion, Republicans, Rick Brattin, science

Source: http://www.addictinginfo.org/2013/02/14/missouri-gop-tries-once-again-to-force-schools-to-teach-creationism-as-real-science/

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Ex-NFL Player Tweets With His Eyes in Fight Against Disease

On Sept. 25, 2006, Steve Gleason blocked probably the most meaningful punt in NFL history. His New Orleans Saints were playing their first home game back in a city that had been devastated by Hurricane Katrina 13 months earlier. The block helped propel the Saints to a poignant 23-3 victory over the Atlanta Falcons. A statue titled "Rebirth" now stands outside the Louisiana Superdome commemorating Gleason's big play.

Gleason was a 5-foot-11, rock solid 212-pound defensive back at the time, a world class athlete playing a gladiator's sport. Today he's 35, confined to a motorized wheelchair and, in his words, has to have "someone else wash my balls." That's thanks to an ongoing battle with the nerve disease amyotrophic lateral sclerosis ? better known as ALS or Lou Gehrig's disease ? that began two years ago.

But, reminiscent of how he helped inspire a community weakened by natural disaster in 2006, Gleason today gives hope and support to a worldwide community weakened by an incurable disease. And what he does would be impossible if not for powerful technology and the digital connectivity of social media.

Gleason in his playing days; Jim Isaac/Getty Images

A product from the company Tobii lets Gleason use his eyes to control a monitor attached to his chair. He's then able to write messages ? including tweets and an email interview for this article ? and browse the web despite not having enough muscle function to do so manually. He's also able to move around, speak, open doors and control household appliances thanks to high-tech tools.

But he's not the only one benefitting. His foundation recently constructed the Team Gleason House for Innovative Living, a $25 million, 18-bed skilled nursing facility in New Orleans that he writes is just the second of its kind worldwide and "will allow ALS patients the same technology and level of independence I have."

Gleason also posts personal tweets, signed "SG," to the @Team_Gleason Twitter account (staff members post non-signed messages) and says social media has helped give ALS patients like himself power they never had before.

"Because of the Internet and social media ALS patients are able to share their experiences and knowledge with each other," he writes. "That has played a massive role in the ALS community. We are able to communicate efficiently on topics of treatment, equipment, technology and other resources. Prior to this, ALS patients were isolated and had to rely on their doctors or medical community for advice."

Raising money and awareness, building the high-tech house ? Gleason says all that is just the beginning of what he hopes to help people accomplish.

"If we continue to fuel the conversation about ALS and put the brightest people together with the people with the right resources, it can be the most significant impact on ALS in 100 years," he writes. "Many people and groups are working toward the same goal and collectively, we can all affect the needed change."

You can learn more about Gleason's foundation here.

Thumbnail image via Cindy Ord/Getty Images

Source: http://feeds.mashable.com/~r/mashable/socialgood/~3/sxYbMNC8xRo/

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California authorities identify remains of fugitive ex-cop

LOS ANGELES (Reuters) - Medical examiners on Thursday positively identified the remains of a fugitive former Los Angeles policeman wanted for a grudge-driven killing spree, capping a manhunt ranked by authorities as the most extensive ever in Southern California.

The remains, charred beyond recognition, were removed from the burned-out ruins of a mountain cabin where Christopher Dorner, 33, made his last stand on Tuesday in a deadly shootout with police that ended with the cabin going up in flames.

Medical examiners used dental records to conclusively determine that the remains were those of Dorner, the San Bernardino Sheriff's Department said, bringing to an official end an exhaustive search for the former Los Angeles police officer who was fired in 2008.

Dorner, who also served as an officer in the U.S. Navy reserves, was accused of killing four people since February 3, including a sheriff's deputy shot during the standoff on Tuesday in the San Bernardino Mountains.

"The investigation continues," Lieutenant Andy Neiman, an LAPD spokesman, told Reuters. "They have to investigate all the fact of these homicides to make sure he acted alone."

Neiman added that to date, there was no evidence to suggest that Dorner had any accomplices.

An angry manifesto found posted last week on Dorner's Facebook page claimed he had been wrongly terminated from the Los Angeles Police Department and vowed to seek revenge by unleashing "unconventional and asymmetrical warfare" on police officers and their families.

He had been on the run since last Wednesday, when he was named as the prime suspect in the slayings of a couple, including the daughter of a retired LAPD police captain, in Irvine, south of Los Angeles.

TRAIL WENT COLD FOR DAYS

The search intensified the next morning after run-ins with police in Riverside County, east of Los Angeles, where Dorner is accused of wounding one officer in a gun battle and later ambushing two policemen at a traffic light, killing one and wounding the other.

Police said Dorner also was believed to have made a failed attempt to steal a boat from a San Diego yacht club.

Law enforcement converged later that day in the San Bernardino Mountains after a pickup truck identified as Dorner's was found abandoned and burning in the snow near the ski resort community of Big Bear Lake. But the trail appeared to go cold as heavy snow fell in the mountains that night.

The ensuing manhunt involved more than 1,000 officers from over a dozen local, state and federal law enforcement agencies and stretched from the Mexican border to the California desert north of the San Bernardinos.

Los Angeles Police Chief Charlie Beck called it the largest in the region's history.

Los Angeles assigned special security details throughout the area to protect about 50 members of the department and their families believed to be in particular danger of being attacked.

But the Big Bear area remained a central focus of the search until Dorner resurfaced two days ago, when he was discovered to have broken into a vacation home, tied up a couple there and made off in their car. The couple managed to free themselves and alert authorities.

After carjacking another vehicle and exchanging gunfire with state game wardens who spotted him making a getaway, Dorner ultimately fled on foot to another cabin and engaged in a shootout with sheriff's deputies who closed in on him there, killing and wounding another.

As authorities shot tear gas canisters into the cabin, the building erupted in flames and burned to the ground. Human remains were found in the rubble that night but it took investigators two days to make a positive ID.

San Bernardino County Sheriff John McMahon said on Wednesday the tear gas canisters may have ignited the blaze but were not intended to do so.

Los Angeles Mayor Antonio Villaraigosa and Police Chief Beck issued a statement Thursday saying that officials from the various agencies that posted a $1 million reward for tips leading to Dorner's capture would meet to "collectively determine whether any individual or individuals qualify for it."

Authorities said it was the largest sum ever offered in a Southern California criminal investigation.

Beck announced last week that he was opening a new inquiry into the disciplinary proceedings that led to Dorner being dismissed in September 2008 on grounds that he lied in accusing a training officer of using excessive force against a homeless man.

A separate inquiry is being conducted into the accidental shooting and wounding of two women by LAPD officers who mistook the pickup truck the women were using to deliver newspapers for the vehicle that Dorner was driving last Thursday.

(Reporting by Steve Gorman; Editing by Cynthia Johnston, Lisa Shumaker and Xavier Briand)

Source: http://news.yahoo.com/california-authorities-positively-identify-remains-fugitive-ex-cop-000506244.html

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Internet Society?s President and Chief Executive Officer Lynn St. Amour to Step Down in February 2014

WASHINGTON & GENEVA--(BUSINESS WIRE)--Internet Society President and Chief Executive Officer Lynn St. Amour today announced that she will leave the Internet Society in February 2014 at the conclusion of her contract. St. Amour joined the Internet Society in 1998 as Executive Director of its Europe, Middle East, and Africa division. She became Executive Director and Chief Operating Officer in 1999 and was appointed President and CEO in March of 2001.

?The Board deeply appreciates Lynn for her exceptional work, passion, and tireless dedication to the organization?s mission of preserving the open, global Internet?

St. Amour will leave a long legacy of accomplishments at the Internet Society, a cause-driven organization dedicated to ensuring the open development, evolution, and use of the Internet for the benefit of all people. During her tenure, the relationship between the Internet?Society and the Internet Engineering Task Force (IETF),?the primary body responsible for the Internet?s core standards and?protocols, was?significantly strengthened and expanded. This increased collaboration and other similar?efforts in the international policy and development realms established the Internet?Society as an internationally respected expert on Internet governance, technical, development, and policy issues. These accomplishments were supported by the growth of the Internet Society?s annual?revenues during this period from just over USD $1M to $35M.

Over the years, the Internet Society has significantly expanded its global impact and today is engaged with a growing, multi-stakeholder community through its Regional Bureaus, 91 Chapters, more than 65,000 Members, and 146 Organization Members. In 2003, St. Amour led a successful bid to operate the .ORG registry and subsequently established a supporting entity, Public Interest Registry, to carry out that responsibility in line with the Internet Society?s principles and values. In conjunction with the Internet Society?s 20^th anniversary in 2012, she developed the Internet Hall of Fame, which annually recognizes Internet visionaries, innovators, and leaders from around the world.

?The Board deeply appreciates Lynn for her exceptional work, passion, and tireless dedication to the organization?s mission of preserving the open, global Internet,? said Eva Fr?lich, Chair of the Internet Society Board of Trustees. ?She is a remarkable leader and has been instrumental to building the Internet Society into a global leader on Internet policy, technical, economic, and social matters. The Board will work closely with Lynn over the next 12 months to implement a succession plan and ensure a smooth transition.?

?The Internet Society is a global organization with a world-class staff, extremely knowledgeable Members and Chapters, and a skilled Board, and we are well positioned with a valuable and unique role at the heart of the Internet?s development. Our future is only limited by our vision,? stated Ms. St. Amour. ?The Internet is at a very important inflection point today. With the Internet Society?s well-respected and global presence, I am confident that the Society will make an even greater impact in the years ahead.?

About the Internet Society

The Internet Society is the trusted independent source for Internet information and thought leadership from around the world. With its principled vision and substantial technological foundation, the Internet Society promotes open dialogue on Internet policy, technology, and future development among users, companies, governments, and other organizations. Working with its members and Chapters around the world, the Internet Society enables the continued evolution and growth of the Internet for everyone. For more information, visit www.internetsociety.org.

Source: http://feeds.businesswire.com/click.phdo?i=1e22b1f139445c10e27c07009510a270

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Michigan Golf Show - Novi, MI Patch

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Source: http://novi.patch.com/announcements/michigan-golf-show-f61cd71a

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AP Source: Miami tests baseball team for HGH. Read more: http://bit.ly/X60Nyw

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Source: http://www.facebook.com/7NewsMiami/posts/253689794765501

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New IU Baseball Facility photo gallery

Nice facility. I grew up playing in a tree house right behind the Sembower batting cages on my way to the Outdoor Pool. Snuck over the fence with my brother to hunt for errant balls more times than I can legally admit to. Loved that place. Sorry, getting a little nostalgic here?

I?m having trouble placing the new stadium. I think I recognize the church in the background, so I?m 90% sure that?s the bypass out past center field. Yes?

Source: http://scoop.hoosiershq.com/2013/02/new-iu-baseball-facility-photo-gallery/

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Steve Jobs Inspired iPhone Concept

In iPhone February 12, 2013 10:01 am

ADR Studio creates some of the coolest concept graphics. This concept is for a ?Steve Jobs inspired? iPhone (5S/6 maybe). It would have a totally glass capacitive screen on a polycarbonate lightweight body with a new core with A6 dual core processor and a 10 megapixel camera. If you look closely you can see ?Steve Jobs? inscribed on the back in handwritten text.

Source: http://feedproxy.google.com/~r/MacSpoilers/~3/EvwhRfqh6_Y/

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What can the ipad do that other cheaper tablets can?t?

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Obama: U.S. will stand by Israel in pursuit of security and long lasting peace

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By Reuters | Feb.13,2013 | 5:56 AM

U.S. President Barack Obama declared that he would stand by Israel in pursuit of security and peace, and that he would do what was necessary to prevent Iran from getting a nuclear weapon, as he delivered a closely watched State of the Union address Tuesday, laying out his priorities for the year ahead and for his newly begun second term in office.

"In the Middle East, we will stand with citizens as they demand their universal rights, and support stable transitions to democracy," said Obama as he spoke on the areas of defense and freedom. "The process will be messy, and we cannot presume to dictate the course of change in countries like Egypt; but we can - and will - insist on respect for the fundamental rights of all people."

He also said the United States "will keep the pressure on a Syrian regime that has murdered its own people, and support opposition leaders that respect the rights of every Syrian."

"And we will stand steadfast with Israel in pursuit of security and a lasting peace. These are the messages I will deliver when I travel to the Middle East next month," he continued.

The speech before a joint session of Congress' two chambers was dominated by domestic issues, but Obama did also refer to his policy on Iran. "[T]he leaders of Iran must recognize that now is the time for a diplomatic solution, because a coalition stands united in demanding that they meet their obligations, and we will do what is necessary to prevent them from getting a nuclear weapon."

"At the same time," he continued, "we will engage Russia to seek further reductions in our nuclear arsenals, and continue leading the global effort to secure nuclear materials that could fall into the wrong hands - because our ability to influence others depends on our willingness to lead."

Withdrawing from Afghanistan

With the economy still the biggest concern of most Americans, Obama devoted less time to foreign policy this year. But he did announce plans to withdraw 34,000 troops from Afghanistan - about half the force there. This announcement is a major development, even if it was highly anticipated, putting the United States on pace to formally finish the protracted war by the end of 2014.

While foreign policy did receive less attention this year, it took on some greater urgency as the speech came hours after North Korea announced that it had detonated a nuclear device. Obama said North Korean leaders "must know that they will only achieve security and prosperity by meeting their international obligations.'

He said "provocations" like the test will further isolate North Korea "as we stand by our allies, strengthen our own missile defense, and lead the world in taking firm action in response to these threats."

The 'unfinished task'

On the domestic front, Obama challenged deeply divided lawmakers to find compromises that would boost job creation and strengthen America's middle class. He conceded America's economic revival is an "unfinished task."

His focus on jobs and growth underscored the degree to which he is still hampered by the economy, even as he pursues a bolder agenda including overhauling immigration laws, enacting stricter gun-control measures and tackling climate change.

Obama also announced that the United States? will begin talks with the European Union on a trans-Atlantic trade agreement, "because trade that is free and fair across the Atlantic supports millions of good-paying American jobs."

The annual address is one of the biggest events in Washington. It is broadcast during prime evening viewing hours by the major television networks, with Washington's most powerful officials - lawmakers, Supreme Court justices, military leaders and Cabinet members - all in attendance and millions of Americans watching from home.

This year's speech came at one of the strongest points in Obama's presidency. He won re-election by a convincing margin, is generally popular, and opposition Republicans appear weakened and fractured. Still, Republicans control the House of Representatives and tough fights loom on the budget and other top issues.

Obama also pledged to work with Russia to seek further reductions in nuclear arsenals and to complete negotiations on the Trans-Pacific Partnership, a trade agreement with the Asia-Pacific region, in addition to pursuing the European agreement.

Bipartisan solutions for climate change

Obama also used the address to press for congressional action on climate change and for stricter gun control laws, both of which face resistance from House Republicans.

On climate change, Obama pledged to work with lawmakers to seek bipartisan solutions but said if Congress doesn't act, he'll order his Cabinet to seek steps he can take using his presidential powers.

Obama said major storms, droughts and wildfires that have afflicted the United States can be considered "just a freak coincidence, or we can choose to believe in the overwhelming judgment of science - and act before it's too late."

His push for overhauling immigration laws had broader appeal. It is one of the few major issues on which badly divided Republicans and Democrats can find common ground. Republicans have long opposed relaxing immigration laws, but are reconsidering their positions as they try to appeal to Hispanics, a growing part of the U.S. electorate that has overwhelmingly favored Democrats.

Republicans: No more spending during deficit

One of the leading Republican voices for immigration reform, Sen. Marco Rubio, was tapped to deliver the official Republican response. Rubio, a 41-year-old Cuban-American, is one of the party's brightest stars and a possible 2016 presidential candidate. But in a sign of the divisions in the party, another, unofficial Republican response will be given by Rand Paul, a senator who is a favorite of the small-government tea party movement.

Republicans remain united in their opposition to Obama's proposals for more spending at a time of huge deficits. Obama said his proposals to increase spending on manufacturing, infrastructure and clean-energy technologies would be fully paid for, though he did not specify how he would offset the cost of his proposals.

"Nothing I'm proposing tonight should increase our deficit by a single dime," Obama said.

He called for increased spending to fix roads and bridges, the first increase in the minimum wage in six years and expansion of early education to reach every American 4-year-old.

He is also calling on Congress to prevent another potential blow to the economy on March 1, when massive, automatic spending cuts are scheduled to take place. Obama has asked lawmakers to block those cuts by approving a mix of tax increases and targeted budget cuts. Republicans oppose any further tax increases beyond those they reluctantly agreed to on the wealthiest households at the start of the year in exchange for extending tax cuts for the vast majority of Americans in effect since George W. Bush's presidency.

"He's gotten all the revenue he's going to get," the Senate's top Republican, Mitch McConnell, said before the speech.

While Obama makes his case for greater gun control, first lady Michelle Obama was sitting with the parents of a Chicago teenager shot and killed just days after she had performed at the president's inauguration last month. Twenty-two House members have invited people affected by gun violence, according to Jim Langevin, a Democratic congressman who helped with the effort. And Republican congressman Steve Stockman said he invited rocker Ted Nugent, a long-time gun control opponent who last year said he would end up "dead or in jail" if Obama won re-election.

Immediately following his speech, Obama was scheduled to hold a conference call with supporters to urge them to pressure lawmakers to back his agenda. He also planned to seek to rally public support with trips this week to North Carolina, Georgia and his home state of Illinois.
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